MELBOURNE: Obese or overweight people may in some cases have improved chances of survival from certain cancers, claims a study which contradicts the regular warnings about the health risks posed by higher body mass index (BMI). Above average or high BMI — a measure of weight relative to height — is often linked to cancers, diabetes, cardiovascular and other diseases, noted the researchers from Flinders University in Australia. Focusing on clinical trials of atezolizumab, a common immunotherapy treatment for non-small-cell lung cancer (NSCLC), the researchers found improved responsiveness to the drug in those with a high BMI. Of the 1,434 participants studied, 49 per cent were normal weight, 34 per cent were overweight and seven per cent were obese. The findings, published in the journal JAMA Oncology, contrast with regular warnings about the health risks of patients who are overweight and obese. “This is an interesting outcome and it raises the potential to investigate further with other cancers and other anti-cancer drugs,” said Ganessan Kichenadasse, a medical oncology researcher at the Flinders Centre for Innovation in Cancer. “We need to do further studies into the possible link between BMI and related inflammation, which might help to understand the mechanisms behind… Read full this story
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